by David Webber

Researchers at the Salk Institute for Biological Studies have identified a new enzyme responsible for the reactivation of our biological clock. The enzyme, JARID1a, is responsible for reactivating the proteins, CLOCK and BMAL1, which responsible our rising levels in another protein PERIOD. The protein called PERIOD is used as an indicator for our bodies telling it when to start up and when to shut down based on the amounts present in the cells. The two other proteins, CLOCK and BMAL1, both effect the production of the PERIOD protein. It has been observed when PERIOD proteins are at their highest levels, around evening, both CLOCK and BMAL1 deactivate, also causing PERIOD levels to reduce, falling levels of PERIOD result in lowering our blood pressure, and also slowing our heart rate and mental processes.
By observing genetically altered human cells, mice and fruit flies that lack the JARID1a gene allowed these discoveries these discoveries to be made. Basically all three type of subject showed low levels of PERIOD protein at its peak time. This caused the animal subjects such as the fruit fly to lose track of time, causing them not to know when to sleep or wake up. However by treating these subjects’ genetic abnormality, by ether inserted JARID1a into their DNA, our by giving them a drug that mimics JARID1a, which allows their biological clocks to operate normally, proves the function of JARID1a.
Question: The article states on how the absence of JARID1a causes abnormal sleep patterns because of its influence on our PERIOD protein production. My question is do other source of abnormal sleep also effect our PERIOD protein such as Environmental changes like daylight savings and jetlag, or chemical like caffeine.
Citation:
‘Alarm clock’ gene explains wake-up function of biological clock.” Biology News Net – Latest Biology Articles, News & Current Events. Salk Institute, 29 Sept. 2011. Web. 4 Oct. 2011
Article URL:
http://www.biologynews.net/archives/2011/09/29/alarm_clock_gene_explains_wakeup_function_of_biological_clock.html




