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DNA and Weight Loss

Posted by: biologystudent | October 3, 2009 | 3 Comments |



by Edward Michalak

On CNN.com, under the Health section, there is a Q&A section where people from around the world can ask questions concerning current topics in the scientific world, and CNN’s medical unit of experts answers the question on a publicly viewed blog in CNN’s health section. On September 18th, 2009, a man from Massachusetts asks if DNA analysis can help identify the best weight loss method. One of the scientists named Dr. Melina Jampolis, a physician nutrition specialist answers the question and discusses the relationships between DNA, genes, and, surprisingly, weight loss.

The physician nutrition specialist begins her answer with the an examination of the genetic aspects of obesity and finishes with the importance of exercise along with a healthy diet. She states that obesity has a genetic component without a doubt, which varies from 40 to 70 percent. There are several hundred genetic regions that are associated with weight loss but there is no observed evidence that directly links the analysis of DNA to formulating an effective weight loss program. Dr. Melina Jampolis also talks about a new field in the world of science called nutra-genomics which studies the interaction of nutrition and genetics.

Later in the post, she states that genes have been identified that are linked to a person’s responsiveness to exercise. She mentions an Obesity Society meeting that found that regular exercise in some people actually switches off obesity causing genes. No other information on this topic was given, but Dr. Jampolis ends the article with recommendations for people who are looking to lose weight the healthy way and urges regular exercise and healthy habits.

The question relates to what my Biology class has been studying over the past few weeks. We have discussed DNA, genes, RNA, and the four organic compounds which were all touched on in Dr. Melina Jampolis’ explanation of the relationship between DNA and weight loss. DNA, also known as deoxyribonucleic acid contains the blueprints for each human being, and genes are parts of DNA that code with proteins. The four organic compounds are carbohydrates, proetins, lipids and nucleic acids. Each can be found in various foods that we consume each day and each compound affects our bodily functions as we move throughout the day.

The article also touches on an ongoing dilemma for many countries, including the United States. Obesity is growing in young children and adults due to a variety of factors. Many programs have been set in place to combat this growing problem and educate children, parents, and adults about the importance of a healthy diet and regular exercise. If further testing and analysis of DNA can show a way to formulate a personalized diet and exercise plan based entirely upon someone’s genetic code, then the levels of obesity in America and other areas all over the world will certainly fall.

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Wow, what an interesting article. I always have found the topic of obesity quite interesting. I am a big advocate of daily exercise and proper nutrition so I have never fully seen an excuse to lead someone to be obese. A genetic link may be an excuse that someone might not be able to beat. However, I can see from your post that you said “an Obesity Society meeting that found that regular exercise in some people actually switches off obesity causing genes.” So my thought is still the same. I know with work and additional time factors leave people with little time but there is no excuse to not be able to go for a short walk or do simple exercises in your home. This is especially true with all the additions of home exercise from the media such as television and internet workout videos to devices that can be bought. Still, i wanted to find out more about your post so I did some research of my own. I found out some really interesting facts.

In my reading of http://generalmedicine.suite101.com/article.cfm/obesity_and_your_genes, I saw how the increase of obesity in the younger generations is making the issue of obesity and it’s root a big issue. The Nova Scotia Health Research Foundation (NSHRF), is particularly concerned with childhood obesity(If you are interested in reading more about Childhood Obesity link to genes check out this resourceful site I found: http://www.medicalnewstoday.com/articles/96594.php#) and therefore performed their own studies to find out more. Through these studies, Dr. Wilkinson found that brain hormonies play a role in regulating body weight and appetitie. And that brain signals sometimes mix with signals from the adipose tissue(where body fat is stores) which may be leading to significant weight gain and in some cases, obesity.

They have also found that Obesity is more than a just a Psychological Disease. Obesity and weight gainage can be brought on by stress and compulsive eating. The site, http://www.newscientist.com/article/dn9002-common-genetic-change-linked-to-obesity.html#, also noted such environmental factors such as stress can affect diet and that this factor, besides genes, that is leading to more than one-third of people in the US being obese. (This site also noted that 30-70% of people are affected by this obesity-leading gene). I know that I personally get stressed out a lot thinking about assignments, both short-term and long-term, as well as, any events or occasions that may be coming up. This can lead to late nights which that lead to late night cravings. For more information on that, I would explore this page because I saw a blog about that! But, it is important to try to have a positive mindset where you know all your long-term goals/activities, but you focus on your short terms to avoid feeling overwhelmed. The process of eliminating unecessary stress with the addition of daily exercise and proper nutrition (limited salty/sugary/fatty foods and instead lots of fiber and nutrition based foods such as fruits and veggies) can help lead to a healthier lifestyle and overall healthy future.

Unfortunately, Dr. Jampolis emphasized what everyone knows but no one wants to hear-that diet and exercise are best for fighting obesity. Finding an effective weight loss plan for an individual through their DNA would no doubt in time become the next South Beach or Atkins diet. In biology we’ve learned that the DNA of all humans are 95% or more similar which makes all the variations in shape and size so interesting. We also learned about genes creating these differences and the article mentions codons that turn on and off obesity genes. Edward’s article is most certainly an interesting one that almost any American can relate to!

This article was really interesting to read and learn more about. The fact that they are included the importance of DNA in the fight against obesity brings in a new way to attack this disease. I like that it is mentioned that for some people obesity can be 40-70 percent due to genetic makeup. I think that they include really useful solutions, that include looking at genetic makeup to produce a more effective diet and work out to combat obesity. I also like that this article has a really universal message.

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